Clinical NutritionHow obesity leads to prediabetes?
Insulin is a hormone released by β-cells of the pancreas which helps to mediate glucose uptake in the target tissues, primarily the liver, muscle, and adipose tissues. Insulin resistance (IR) is defined as an impaired biological response to insulin stimulation of these target tissues. It affects the glucose uptake in the cells, resulting in increased secretion of insulin from β-cells resulting in hyperinsulinemia. If it goes uncontrolled, it can result in various metabolic consequences like hyperglycemia, dyslipidemia, visceral adiposity, hypertension, hyperuricemia.
