Impact of weight loss on Leptin

INFS
INFS

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Fat Loss
About Leptin and its impact on Body Composition by Praveen Budhrani

During your dieting journey you would have experienced that after a few weeks things start getting harder- weight loss slows down, performance in the gym starts to decline, cravings start to crop up, etc. The important thing is Leptin sensitivity. Sometimes overproduction of a hormone can make your body’s cells immune to its effects. Thereby, creating a situation where despite having high levels of Leptin, indicating high satiety, the signal does not reach the desired cells. This is a breakdown of the regulation mechanism and it makes us feel hungrier, less motivated, low mood and less energetic, etc. Leptin might be playing some role in this slowdown. Leptin is involved in many functions including regulating appetite, energy balance, motivation, mood, and sex drive, etc. [1] [2] [3]. Leptin’s primary job is maintaining body composition. It signals the brain to indicate satiety levels. The important thing is Leptin sensitivity. Sometimes overproduction of a hormone, can make your body’s cells immune to its effects. Thereby, creating a situation where despite having high levels of Leptin, indicating high satiety, the signal does not reach the desired cells. This is a breakdown of the regulation mechanism and it makes us feel hungrier, less motivated, low mood and less energetic, etc. The good news is that as overweight people start to slowly lose weight in moderation, their Leptin sensitivity improves [4] [5]. Other than moderate weight loss, getting enough sleep [6] [7] and regular exercise has also been associated with improved Leptin sensitivity [8] [9]. Reference: [1] Park, H. K., & Ahima, R. S. (2015). Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism. Metabolism, 64(1), 24-34. [2] Farooq, R., Ullah, S. L., & Ishaq, H. (2013). Relation of serum leptin with sex hormones of obese infertile men and women. Journal of Applied Pharmaceutical Science, 3(1), 60. [3] Zou, X., Zhong, L., Zhu, C., Zhao, H., Zhao, F., Cui, R., ... & Li, B. (2019). Role of Leptin in mood disorder and neurodegenerative disease. Frontiers in neuroscience, 13, 378. [4] Zhao, S., Zhu, Y., Schultz, R. D., Li, N., He, Z., Zhang, Z., ... & Deng, H. (2019). Partial leptin reduction as an insulin sensitization and weight loss strategy. Cell metabolism, 30(4), 706-719. [5] Hernández Morante, J. J., Díaz Soler, I., Muñoz, J. S. G., Sánchez, H. P., Barberá Ortega, M., Martínez, C. M., & Morillas Ruiz, J. M. (2020). Moderate Weight Loss Modifies Leptin and Ghrelin Synthesis Rhythms but Not the Subjective Sensations of Appetite in Obesity Patients. Nutrients, 12(4), 916. [6] Spiegel, K., Leproult, R., L’Hermite-Balériaux, M., Copinschi, G., Penev, P. D., & Van Cauter, E. (2004). Leptin levels are dependent on sleep duration: relationships with sympathovagal balance, carbohydrate regulation, cortisol, and thyrotropin. The Journal of clinical endocrinology & metabolism, 89(11), 5762-5771.
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